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WJB, ICC, and ME are authors of the original ARRIVE guidelines. NPdS, KL, VH, and EJP are employees of the NC3Rs.Ĭompeting interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: AA is the editor in chief of the British Journal of Pharmacology.
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The work is made available under the Creative Commons CC0 public domain dedication.įunding: This work was supported by the National Centre of the Replacement, Refinement & Reduction on Animals in Research (NC3Rs, ).
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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. PLoS Biol 18(7):Īcademic Editor: Isabelle Boutron, University Paris Descartes, FRANCE
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(2020) Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. This document also covers advice and best practice in the design and conduct of animal studies to support researchers in improving standards from the start of the experimental design process through to publication.Ĭitation: Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, et al. It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature. This explanation and elaboration document was developed as part of the revision. The revised guidelines are published alongside this paper.
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We have revised the ARRIVE guidelines to update them and facilitate their use in practice. Despite widespread endorsement by the scientific community, the impact of ARRIVE on the transparency of reporting in animal research publications has been limited. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Transparent and accurate reporting is vital to this process it allows readers to assess the reliability of the findings and repeat or build upon the work of other researchers. Improving the reproducibility of biomedical research is a major challenge.